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Metformin typically achieves A1C reductions of 1.0-1.5% as monotherapy, depending on the baseline level

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However, given the large and growing body of preclinical literature highlighting mechanisms outside of body weight contributing to sex differences in effects of GLP-1R agonism (eg, interactions with estrogen), the case for meaningful and potentially clinically relevant differences remains, if not strong, then at least certainly warranting careful attention to sex as an important variable in GLP-1 system research