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The European Medicines Agency classified NAION as a very rare but recognized side effect of semaglutide in June 2025, affecting up to 1 in 10,000 users

The term covers several distinct approaches from taking smaller doses to extending dosing intervals none of which have been validated in randomized controlled trials

[DOI] [PubMed] [Google Scholar] 6.Sikiric P, Seiwerth S, Grabarevic Z, Petek M, Rucman R, Turkovic B, et al

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For current practice, the most defensible use of GLP-1RAs is as a time-bounded metabolic optimization strategy in women with meaningful obesity/insulin-resistance burden, with reproductive endpoints interpreted as potential downstream gains rather than guaranteed direct effects (111, 112, 124)

Gaucher disease glucocerebrosidase and -synuclein form a bidirectional pathogenic loop in synucleinopathies
