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Keywords: GLP-1 receptor agonists, Neuroprotection, Synaptic plasticity, Central nervous system, Neurodegenerative diseases Graphical abstract Introduction GLP-1 receptor agonists (GLP-1RAs) are well-established treatments for type 2 diabetes mellitus (T2DM) and obesity, providing effective glycemic control, weight loss, and cardiovascular benefits [[1], [2], [3]]

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This wide-ranging receptor localization emphasizes GLP-1s diverse physiological impacts and supports its role as a potential therapeutic agent in treating a variety of disorders, including metabolic dysfunctions, cardiovascular diseases, and chronic inflammatory conditions

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