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While NZ doesnt yet fund metformin for MS, the MACSiMiSE-BRAIN trial overseas is exploring its neuroprotective potential in progressive MS

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Sources Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes

[DOI] [PubMed] [Google Scholar] 61.Zhong J., Rajagopalan S

Lixisenatide inhibits neuroinflammation by promoting the proteasomal degradation of thioredoxin-interacting protein (TXNIP) in ocular tissues via the PI3K/Akt signaling pathway, an effect more potent than that of insulin

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