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Following the first injection, initial effects on blood glucose typically begin within the first week , though modest initially

This may suggest that the observation of a benefit of the GLP-1 RAs on heart failure hospitalisation as found in the meta-analysis by Sattar and colleagues is driven by data from AMPLITUDE-O and Harmony Outcomes

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The phenomenon may be linked to rapid gastric distension triggering a vagus nerve reflex though this remains a hypothesis rather than an established mechanism

A randomized study on the effect of weight loss on obstructive sleep apnea among obese patients with type 2 diabetes: the Sleep AHEAD study

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