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doi: 10.1016/j.addr.2018.07.009

It's important to note that not all healthcare providers offer MTHFR gene mutation testing, and the test may not be covered by insurance in all cases

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Between 10% and 20% of PNH patients experience clinically significant loss of red blood cells outside of the blood vessels, a condition known as extravascular haemolysis, and continued anemia symptoms when on C5 inhibitors
