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doi:10.1002/dmrr.1080 73

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Menopause can affect metabolism, fat distribution, sleep, insulin sensitivity and body composition

Representative experimental areas include: Metabolic disease and obesity: Murine models show that MOTS-C improves insulin sensitivity, enhances skeletal muscle glucose uptake, promotes lipid utilization, and reduces dietinduced obesity while improving glucose tolerance

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Rushing dose increases often leads to intolerable side effects that may cause patients to stop treatment prematurely