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Physical exercise stimulates the release of endorphins and promotes neurogenesis, whereas vitamin D influences serotonergic neurotransmission and provides neurotrophic support, thereby contributing to enhanced mood and cognitive resilience ( Figure 3 )

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After that, once every two to four weeks is typical for maintenance

Fleming et al., 1997)

Adaptations in the local microenvironment lead to a reprogramming of energy metabolism to accommodate these changes

Yuen MF, Asselah T, Jacobson IM, Brunetto MR, Janssen HLA, Takehara T, Hou JL, Kakuda TN, Lambrecht T, Beumont M, Kalmeijer R, Guinard-Azadian C, Mayer C, Jezorwski J, Verbinnen T, Lenz O, Shukla U, Biermer M, REEF-1 Study Group