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Since GHK-Cu carries copper, taking too much for too long may be a concern for people with liver issues, copper metabolism concerns, or pregnancy/nursing considerations

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doi: 10.1016/j.taap.2009.07.024

Data gathered over a 7-year period in the United Kingdom suggested that the undisciplined use of these preparations increased mortality in asthmatic patients

[DOI] [PubMed] [Google Scholar] 188.Melhem NM, Brent DA, Ziegler M, Iyengar S, Kolko D, Oquendo M, Birmaher B, Burke A, Zelazny J, Stanley B, Mann JJ

The stress and strain on the ACL due to increased anterior tibial translation can lead to microstructural changes within the collagen matrix