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, & Leslie, R

Sources: CLC016638.A This content is not intended to be a substitute for professional medical advice, diagnosis or treatment

Herrington WG, Staplin N, Wanner C, et al

Patients should be reassured that seeing small bubbles in their GLP-1 pen is normal and not dangerous

With the GLP-1 receptor there is the pathway linked to insulin control, but also a pathway that recruits the signalling molecule beta arrestin, which causes the side effects but also results in the whole receptor and drug molecule being taken inside the cell, shutting down any further activity

GLP-1 is released in the gut after eating and travels through the bloodstream and vagus nerve to the brainstem and hypothalamus, where it slows gastric emptying, enhances satiety, and modulates reward pathways