overeating on retatrutide 1 year reta : r/Retatrutide Retatrutide Side Effects Guide: 21

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Infusion of GLP-1R agonists in these brain nuclei possibly targets the neural mechanisms underlining food motivation and bypasses the hindbrain GLP-1 nausea circuitry

Labeled titrations

The most common reason for stopping was gastrointestinal side effects nausea and vomiting

Gallbladder disease Cholelithiasis and cholecystitis have been reported, consistent with rapid weight loss generally

The authors conclude: In this real-world study where half of patients discontinued GLP-1-based treatment within a year after initiation, not losing weight was associated with worse clinical outcomes while larger reductions were associated with decreased risks