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Across the available retrospective cohorts, treatment discontinuation rates due to adverse events were generally low

An interesting alternative explanation for slightly smaller efficacy of the OAB medications in those with diabetes relates not to pharmacodynamic differences but rather to a reported lesser adherence to muscarinic antagonists prescribed as OAB medication in obese patients (Lua et al

[DOI] [PubMed] [Google Scholar] 110.Lien F., Berthier A., Bouchaert E., Gheeraert C., Alexandre J., Porez G., Prawitt J., Dehondt H., Ploton M., Colin S., et al

Safety concerns were also raised in a phase 1 trial investigating the GLP-1R/GCGR agonist NNC9204-117, where a dose-dependent increase in heart rate was observed, in addition to increased markers of inflammation, hepatic disturbances, impaired glucose tolerance, and reduced blood levels of some amino acids despite clinically relevant weight loss (Friedrichsen et al

doi: 10.1016/j.molmet.2013.06.003

Equally important is the clarity of how the platform handles verification checks