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This is true in general nutrition, but it becomes critically important when your digestive system is operating under the influence of GLP-1 receptor agonists

This might include eating on a schedule rather than waiting for hunger cues, since GLP-1 therapy specifically blunts those cues

Even when mitigating measures are considered, adverse events (AEs) related to the GI tract are common among oral semaglutide patients

Thus, semaglutide shows reduced -arrestin recruitment and receptor internalization compared to endogenous GLP-1

"A patient who tolerates semaglutide well and achieves meaningful, sustained weight loss doesn't necessarily need to switch," says Srivastava

Clin Gastroenterol Hepatol 2022