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Discontinuation Trends and Persistence Patterns Despite the clinical benefits of GLP-1 receptor agonists, discontinuation remains a challenge

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This approach common to GLP-1 and related receptor agonist therapies is designed to minimise gastrointestinal side effects such as nausea, vomiting, and diarrhoea, which are among the most frequently reported adverse events with this class of medication

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(2018) found that male mice treated with 17-estradiol had higher levels of urea cycle intermediates and certain amino acids in the liver, and that these changes disappeared in a cohort of castrated male mice, suggesting that male-specific benefits are mediated through alterations to processes involving male gonadal hormones