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Conversely, MB markedly suppressed AKT phosphorylation, suggesting reduced inhibitory control over GSK-3 and potential overactivation of this kinase

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By the end of the 40-week trial, the estimated changes for A1C were -1.86% for those receiving 1 mg of semaglutide and -2.01%, -2.24%, and -2.30% for those receiving the respective tirzepatide doses of 5 mg, 10 mg, and 15 mg