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The 72-hour rule is a safety floor for occasional schedule adjustments, not a minimum dosing interval for regular use

Some people reach their goals at 5 mg or 10 mg, and your provider will determine whats appropriate based on your response and tolerability

The 2.5mg starting dose is subtherapeutic for weight loss in many people

That doesnt mean that you need to inject the medication straight from the refrigerator, however

Simultaneously, by stimulating the GLP-1 receptor, the medication reduces appetite and food intake , leading to weight loss

That window is the time to build the eating, movement, and behavioural habits that prevent weight regain if you come off the medication in the future