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Effect of delayed feeding post-hatch on expression of tight junction- and gut barrier-related genes in the small intestine of broiler chickens during neonatal development

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Levels of KL-6 (a marker for AEC injury), ColIV1, and ColIV3 (markers for BM destruction) were significantly elevated in the serum of animals in the induced group, signifying that BLM caused AEC damage that resulted in the release of KL-6 23 and recruitment of inflammatory cells (e.g., monocytes) leading to the release of MMPs which results in further degradation of the surrounding BM and the release of collagen type IV fragments into the blood circulation 58,64

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Additionally, it activated the adenylyl cyclase (AC)/cAMP/PKA pathway via PGI2 and stimulated the 2-adrenergic receptor