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Head-to-head efficacy comparison Retatrutide versus semaglutide is not even close in terms of raw weight loss numbers

Effects on gastric emptying are significant and appear to lessen with long-term use, possibly due to tachyphylaxis of vagal nerve activation

The question of whether the increased cardiac workload (both rate and force) could cause long-term cardiac remodeling remains open

doi: 10.1016/j.jacc.2024.04.022

& Billiar, T

In terms of structure, several GLP-1RAs have been developed based on the naturally occurring protein exendin-4 (from the Gila monster, a lizard found in New Mexico and Arizona), which shares 53% homology with native (human) GLP-1 [49,50,51]