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Ji G, Zhang C, Lu AP

Effect of cannabinoids on ADT-treated patients One of the reasons behind PC recurrence and progression in the ADT-treated patients is the differentiation of the prostate cancer cells into the neuroendocrine (NE)-like cells which correlates with tumor progression and poor prognosis (Bennett et al

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This dualistic outcome likely stems from the distinct physiological roles of lactate and associated acidosis: elevated lactate itself may not impair muscle function and might even support performance, yet the concomitant severe intracellular acidosis (pH 6.56.2), especially in fast-twitch fibers, reduces calcium sensitivity and impairs myosin ATPase activity, ultimately inducing muscle fatigue

Varma, S
