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Despite the supportive scientific evidence provided, the substantial clinical promise is, however, tempered by several translational barriers that must be surmounted before either can achieve routine clinical adoption

In vitro cell uptake tests revealed that these nanoparticles exhibited targeted properties for glioma cells, and compared with non-targeted nanoparticles, targeted nanoparticles showed better BBB penetration in the in vitro model [383]

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Clinical trials as mentioned by the research studies have used weight-based dosing (for example, 0.03 mg/kg twice daily in a proof-of-concept surgical trial)