tirzepatide cause tiredness Does Make You Tired? Updated 2025 Does Tirzepatide Make You Tired?

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Tirzepatide activates GLP-1 and GIP receptors in your brain and digestive tract, intentionally slowing gastric emptying to increase fullness signals

Medications like Mounjaro and Zepbound contain tirzepatide and are prescribed for metabolic conditions

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In parallel, GLP-1 receptor activation in the gastrointestinal tract slows gastric emptying and alters gastric motility, leading to gastric distension and increased vagal afferent firing