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Treatment of T2D includes lifestyle changes such as diet, exercise, and nutraceuticals, as well as administration of medications such as metformin

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This elevated risk reinforced the post-marketing signals regulators were already seeing

Before 2022, Orlistat capsules were the only medication approved in China for treatment of obesity and overweight, which left a massive clinical need for compliant, safe, and effective weight control drugs unmet, the company wrote

Pathological increases in blood glucose, the central metabolic defect in T2D, occur chiefly due to failure of pancreatic beta cells to release enough of the glucoregulatory hormone insulin, and overweight-related tissue resistance to insulin action

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