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According to Sarwer and Maccarone, scientists believe these shifts in mood are caused by how the drug changes the brain's central reward pathways by diminishing responses to the neurotransmitter dopamine

Even the FDA acknowledged that "patients and prescribers may still see intermittent and limited localized supply disruptions as the products move through the supply chain from the manufacturer and distributors to local pharmacies." The American Society of Health-System Pharmacists' shortage list continues to show both semaglutide and tirzepatide injection in shortage

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Their single-molecule design optimally integrated the incretin effects of both hormones, demonstrating superior efficacy compared to traditional GLP-1RAs

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