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Likewise, among adults with overweight or obesity who completed a 20-week run-in period with subcutaneous semaglutide, 2.4 mg once weekly, maintaining treatment with semaglutide resulted in reduction of mean body weight of 7.9 %, while switching to placebo resulted in increased body weight of 6.9 % over the following 48 weeks [172]
The gutbrain axis enables bidirectional communication between the brain and the gastrointestinal system, involving neuroendocrine pathways, the vagus nerve, immune factors, and microbiota (Carabotti et al., 2015
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Orforglipron, as a small-molecule drug, is cheaper and easier to produce at scale
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Nutrients 10 (9), 1285
