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Clinical trials that demonstrated significant weight loss included structured dietary counseling and exercise recommendations as part of the protocol

Circulation 136:849870 Honigberg MC, Chang LS, McGuire DK, Plutzky J, Aroda VR, Vaduganathan M (2020) Use of Glucagon-Like Peptide-1 Receptor Agonists in Patients With Type 2 Diabetes and Cardiovascular Disease: A Review

Ryan David Brown for The New York Times Those that have stopped taking these weight loss drugs have experienced spikes in blood sugar leading to trips to the emergency room for exhaustion, a return of cravings and weight gain

Early Intervention: Provides an opportunity for individuals to begin preventive therapies for age-related conditions

The clinical evidence for these multi-additive combinations is limited, but anecdotal reports from providers and patients are generally positive
