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Today it is recognised that the hypothalamus is a key region of the brain that is implicated in homeostatic regulation and is suggested to be an integral centre for the control of feeding behaviour [15, 16]
Khamidova, A
Where semaglutide targets one receptor and tirzepatide targets two, retatrutide activates three making it the most complex incretin-based peptide currently under active research investigation

This dual effect could explain why GLP-1 analogues, unlike dexamethasone, improve both synovitis and fibrosis in preclinical models

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After four weeks, the dose increases to 0.5 mg weekly, and if needed, can be increased further up to a maximum of 2.4 mg weekly
