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Whether these differences can explain metabolic outcomes will be explored in detail below (Figure 2)

Pang J, Feng JN, Ling W, et al

As fat volume decreases, patients may develop: Loose skin Deflated tissues Facial volume loss Breast deflation Hanging abdominal skin Ironically, many patients become healthier than ever while simultaneously becoming more self-conscious about loose skin

Its not meant to be taken like that, said Apovian

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(2025) [40], were conducted in adults with obesity (typically BMI 30 kg/m 2 ), most of whom had comorbid type 2 diabetes and consistently excluded individuals with active, severe, or unstable psychiatric disorders