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J Mol Neurosci 18:714 [DOI] [PubMed] [Google Scholar] Harkavyi A, Abuirmeileh A, Lever R, Kingsbury AE, Biggs CS, Whitton PS 2008 Glucagon-like peptide 1 receptor stimulation reverses key deficits in distinct rodent models of Parkinsons disease

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Leptin is produced not only in the adipose tissue but also in the gastrointestinal tract, particularly in the stomach, where it has been shown to protect the gastric mucosa against various topical irritants and ulcerogens, acting, at least in part, via enhancement of mucosal blood flow due to increased production of nitric oxide (NO) caused by upregulation of NO synthase as well as the activation of brain-gut axis pathways (48, 49)