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Administration considerations : Oral semaglutide (Rybelsus) must be taken on an empty stomach with no more than 4 ounces of plain water, at least 30 minutes before the first food, beverage, or other oral medications of the day

[DOI] [PMC free article] [PubMed] [Google Scholar] 65.Li J-Y, Cui L-Y, Sun X-H, Shen D-C, Yang X-Z, Liu Q, Liu M-S

British Journal of Pharmacology, 178(S1), S27S156

The best combination for weight loss success is physical activity, managing stress levels and eating a diet consisting of fruits, vegetables, healthy fats and minimal ultra-processed foods