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Insufficient testing No data to show they are safe or effective: Most of these substances are not clinically tested on humans, and none of them have undergone the extensive trials required to gain FDA approval as a medicine
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doi: 10.1055/s-0041-1741560 [DOI] [PMC free article] [PubMed] [Google Scholar] 50

If considered for the indication of obesity in HFrEF, caution and close monitoring are warranted.

In fact, some research has indicated that semaglutide users have had a 266% increase of DVT, but the link between semaglutide and the occurrence of DVTs is not immediately clear

G., Blissmer, B