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Acknowledgements This research was funded by the National Natural Science Foundation of China (92374113 and 82472128 to Z.L.), the National Key Research and Development Program of China (2022YFA1104300 to Z.L.), the Interdisciplinary Basic Frontier Innovation Program of Suzhou Medical College of Soochow University (YXY2303025 to Z.L.), the Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions (22KJA310004 to Z.L.), Suzhou Fundamental Research Project (SJC2023001 to Z.L.), and the Project of State Key Laboratory of Radiation Medicine and Protection, Soochow University (GZK12023028 to H.L.)

4a, b and Extended Data Fig

There is evidence that different species of protein aggregates associated with neurodegenerative diseases may act to promote ROS generation

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For the past decades, several studies have revealed that epileptic activities are associated with vitamin B12 deciency, as proven by Sklar (1986) [18], which led to emerging evidence regarding the neuroprotective effects of vitamin B12, as found by Romano et al

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