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Environmental Toxins: Exposure to heavy metals, pesticides, and air pollution increases the demand for glutathione in the liver

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salad dressings, and pre-assembled, pre-portioned, pre-packaged, and ready-to-eat meals and preparations consisting of the foregoing

The cause is a restriction of the activity of cytochrome P450 CYP3A4 in the CYP enzyme system in the liver induced by pro-inflammatory cytokines (e.g., IL-6, TNF-, and IL-1Ra), an effect that is stronger at high concentrations of these cytokines (i.e., during highly perturbated and excessive inflammatory events) [18,19,20,21]