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Month 2: If you're tolerating the starting dose well, your provider will increase it to the next step, typically 0.5 mg weekly

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A 2025 narrative review of clinical trials confirmed that across completed randomised and indirect comparisons, tirzepatide consistently outperforms semaglutide in body weight and HbA1c reduction [2]

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From a clinical perspective, these findings suggest that incretin-based therapies can be effectively implemented in routine practice for weight management in adults with overweight or obesity without diabetes