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Platinum-based compounds including cisplatin and oxaliplatin, directly binds to the DNA and form platinum adducts in proliferating malignant cells, which in turn inhibits DNA replication that kill the cancer cells (Podratz et al., 2011)

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It is not a drug, food, or supplement and is not intended for human consumption, therapeutic use, diagnostic use, or veterinary use

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Indeed, the GSH/GSSG ratio is greatly reduced in NCI H23 cell line, explaining the higher DNA damage induction in these cells causing higher cell sensitivity to cisplatin

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Yatsunenko et al., 2012

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However, before any meaningful progression can occur in linking cuproptosis and copper to targeted cancer therapy, the regulatory mechanisms underlying cuproptosis must be determined [5]

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