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Nature Reviews Endocrinology, 8, 728-42

For some men its a reasonable option

Compounded semaglutide from licensed 503A pharmacies contains the identical GLP-1 receptor agonist molecule and undergoes similar quality testing

doi: 10.1056/NEJMoa1600869 [DOI] [PMC free article] [PubMed] [Google Scholar] 14.Wiggins T, Antonowicz SS, Markar SR

This is a dietary supplement formulated to support the nutritional needs of adults who are already taking GLP-1 medications under medical supervision

In clinical trials, people taking Contrave lost an average of about 8% of their initial body weight after 56 weeks, compared to less than 2% in those who took a placebo (inactive medicine)
