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Treatment with metformin might reverse fatty liver disease in obese, leptin-deficient mice by inhibiting the hepatic expression of tumour necrosis factor (TNF)- and TNF-inducible factors that promote hepatic lipid accumulation and ATP depletion [98]

Weight regain can occur if medication is stopped without maintaining supportive lifestyle changes, as weight regulation is influenced by long-term metabolic factors

Treatment That Supports the Whole Person Effective eating disorder treatment integrates therapy, nutritional counseling, medical monitoring, and family or community support

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Korner et al
