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Probable mechanism of action of diazene antibiotics
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ALDH2 variants can slow acetaldehyde clearance, leading to flushing, nausea, and headaches
Key questions including the existence of lactyl-CoA in vivo, the physiological relevance of non-enzymatic lactylation, and the identification of specific reader proteins must be resolved before lactylation can be fully established as a stable and universal regulatory mechanism
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Second, Levene's test was used to check the homogeneity of variance, and the Welch test was used when the data did not satisfy the homogeneity test
