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Effects were stratified by pre-existing diabetes status to account for different treatment indications
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Statements Author contributions SM, SP, MA, DeL, PK, SA, FN and JR conceived of the article, compiled the literature, and interpreted its contents

These indirect mechanisms allow for central nervous system modulation without requiring substantial penetration of the blood-brain barrier, though direct human data on CNS distribution of long-acting incretin agonists remain limited
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Both aerobic exercises and strength training have proven effective in improving insulin sensitivity and metabolic health
