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Amplicon sequencing data were processed using mothur version 1.48 62 , with a workflow adapted from the MiSeq SOP ( accessed in Mar 2025), and incorporating slight procedural adjustments 61

The long-term survival rate of Adh5 / mice was also almost the same as that of wild-type mice [14]

10.1371/journal.pcbi.1004115 15 BaoN.ChenZ.LiB.YangH.LiX.ZhangZ

doi:10.1016/j.cell.2012.12.029 pmid:23374344 Zhang Y, Kuang Y, Xu K, Harris D, Lee Z, LaManna J, Puchowicz MA (2013) Ketosis proportionately spares glucose utilization in brain

Data extraction and verification were conducted by at least two reviewers