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Description
In addition, G protein-coupled excitatory GLP-1 receptors are located in central regions subserving disparate brain functions (eg, ventral tegmental area, nucleus accumbens, hippocampus, lateral septum, hypothalamus)
They enhance glucose-dependent insulin secretion, suppress glucagon release, slow gastric emptying, and reduce appetite via central hypothalamic pathways, leading to lower energy intake and improved glycemic control
Together, these rat studies suggest that the weight-lowering potential of GLP-1MK-801 is not associated with exacerbated nausea
doi: 10.1038/s41586-018-0849-9 6 YustaBBaggioLLKoehlerJHollandDCaoXPinnellLJet al
Cent Eur J Immunol
This can cause problems like fatigue, hair loss, or muscle weakness
