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Consider initial therapy at this stage when blood glucose 300 to 350 mg/dL (16.7 to 19.4 mmol/L) and/or HbA1C 10%-12% (86 to 108 mmol/mol), especially if the patient is symptomatic or if catabolic features (eg, weight loss, ketosis) are present, in which case basal insulin + mealtime insulin is the preferred initial regimen

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showed a significant reduction in oxidative stress, which resulted from an improvement in SOD, MDA, GSH, TAC, and CAT after supplementation with three different dosages (2505001000 mg/kg) of glutamine for over two months [17, 18]

HA receives research funding from Phenomix Sciences and the USA National Institute of Health (K12AR084222)