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Dose-specific weight loss outcomes for tirzepatide Source: SURMOUNT-1 trial (Jastreboff et al., NEJM 2022)

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Animals were dosed subcutaneously with either IcoSema (4200 nmol/mL icodec and 490 nmol/mL semaglutide) at a single dose containing 7.5 nmol/kg icodec and 0.875 nmol/kg semaglutide ( N = 8) or separate similar injections of icodec and semaglutide ( N = 8)

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This combination can be important for people who struggle to stay on semaglutide because of nausea

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