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Given the heterogeneity of study designs and outcomes, results were synthesized using a narrative approach

It is essential for patients to remain well-hydrated, aiming for at least 2 liters of water daily, as dehydration can exacerbate feelings of fatigue

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DXA body composition data from retatrutide's Phase 2 sub-study, published in The Lancet Diabetes & Endocrinology (June 2025), confirmed that lean mass loss occurs alongside fat loss, consistent with patterns seen across the GLP-1 drug class

Im increasingly concerned about a trend Im seeing in parts of longevity/functional medicine and biohacker culture, where the boundaries of legal and ethical behavior are being stretched - often crossed - by clinicians, pharmacists, and influencers

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