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GLP-1 RAs are used for managing blood glucose levels in people with type 2 diabetes mellitus and have also been licensed for use in weight loss treatment

Nevertheless, bone consequences of intentional weight loss interventions in PwO are well known: (i) significant weight loss induced by caloric restriction and bariatric surgery results in accelerated bone turnover and bone loss, and (ii) unlike caloric restriction interventions, PwO experience a substantial deterioration in bone microarchitecture and strength associated with an increased risk of fracture after bariatric surgery especially malabsorptive procedures

There is currently no strong evidence that GLP-1 receptor agonists directly cause thrombosis or blood clots

Understanding this timeline helps you prepare and distinguish normal adaptation from serious concerns

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