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"Once-Weekly Semaglutide in Adults with Overweight or Obesity." New England Journal of Medicine , 2021

doi: 10.1016/0091-3057(93)90169-t 85 HayDLChenSLutzTAParkesDGRothJD

Retatrutide, a triple agonist targeting GIP, GLP-1, and glucagon receptors, represents a further step in efficacy, with 24.2% weight loss achieved within 48 weeks in phase 2 studies (13) and 29% weight loss achieved over 68 weeks in a phase 3 study (16)

It works on your brains appetite centers and makes you feel full sooner and for an extended period

Joseph Rizzo, director of the Neuro-Ophthalmology Service at Mass Eye and Ear and the Simmons Lessell Professor of Ophthalmology at Harvard Medical School, was published in JAMA Ophthalmology

Dysaesthesia (an abnormal skin sensation) affected around 21% of participants at the 12 mg dose