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Nat Rev Neurol 12(8):455464 Global regional (2018) and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 19902017: a systematic analysis for the Global Burden of Disease Study 2017
However, adherence to physical activity remains a major challenge, often limited by perceived effort, time constraints, and lack of behavioral support

[2] If you're planning pregnancy, contact your provider well in advance, as these medications should be discontinued (semaglutide at least 2 months before planned conception) due to limited safety data in pregnancy

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It remains unlicensed, unavailable outside authorised clinical trials, and prohibited under WADA and UKAD anti-doping rules
