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Plasma concentrations decline significantly with age from ~200 ng/mL at age 20 to ~80 ng/mL by age 60 making it a compelling target for age-related tissue maintenance and periodontal health

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When this happens, low levels of intrinsic factor produce symptoms of juvenile pernicious anemia in patients younger than age 10

Deficiency is also prevalent in seniors because the capacity to absorb vitamin B12 can diminish with age

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Neither approved nor specifically prohibited by Health Canada, it remains available as a research chemical for laboratory investigation