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Abstract Peptide agonists of the glucagon-like peptide-1 receptor (GLP-1R) have revolutionized diabetes therapy, but their use has been limited by the requirement for injection

BIBLIOGRAPHY 1 - Wegovy PI 2 - North Carolina Pharmacy Practice Act

E., Wirth J., et al

GLP-1RA Liraglutide Semaglutide Efpeglenatide Glucose lowering effect CV system protection effect Kidney protection effect Nonalcoholic fatty liver disease GIP/GLP1 receptor coagonists: tirzepatide Amylin/GLP1 receptor coagonists: CagriSema (cagrilintide+semaglutide) Glucagon/GLP1 receptor coagonists: survodutide GIP/GLP1/glucagon receptor triple coagonists: retatrutide Obesity is a disease that can be treated with targeted pharmacotherapy in addition to lifestyle modification and behavioral interventions

Other unimolecular triple agonists and combination regimens involving tirzepatide with additional mono agonists are also in development

A meta-analysis of clinical trials, including data from Novo Nordisk itself, found higher incidence of optic ischemic neuropathy in GLP-1 groups compared to placebo