glp 1 drugs and anesthesia 🇬🇧 Perioperative Management of New Popular Agents: GLP-1 Agonists (GLP-1 RA: semaglutide, tirzepatide) These delay gastric emptying → patients may have a “full stomach” despite fasting This increases risk of regurgitation Are Serious Anesthesia Risks of

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1 In one placebo-controlled trial with semaglutide (Trial to Evaluate Cardiovascular and Other Long-term Outcomes with Semaglutide in Subjects with Type 2 Diabetes [SUSTAIN 6]), 10 there was a significant early increase in diabetic retinopathy in patients allocated active therapy, which has been attributed to the rapidity and magnitude of improved glycaemic control (as has been observed in previous studies involving intensive insulin treatment) rather than being a direct adverse drug effect