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[80] Just a snippet on one of the mechanisms - whereas creatine is a phosphate donor, betaine acts as a methyl donor (remember, its scientific name is trimethylglycine )

312 , C3C15 (2017)

Ignition of the -AR/cAMP pathway is, by no doubts, the mainspring of cardiac fight-or-flight reaction, ultimately causing positive chronotropic, lusitropic and inotropic effects, mostly through PKA-dependent phosphorylation of sarcomeric proteins and molecular players regulating Ca 2+ dynamics (Li et al., 2000

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For best results, consistent use over a few weeks to months is advised

DBs present address is: Department of Diagnostic Radiology, Mayo Clinic, Rochester, Minnesota, USA